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Epigenetic Biomarkers and Diagnostics

Epigenetic Biomarkers and Diagnostics

by Jose Luis Garcia-Gimenez

Editorial: Elsevier Science
ISBN: 9780128018996
Número de páginas: 696
Formatos: pdf, ePub, mobi, fb2
Tamaño de archivo: 18 Mb
Fecha de publicación: 2020-05-21


Epigenetic Biomarkers and Diagnostics comprises 32 chapters contributed by leading active researchers in clinical epigenetics. The book is divided into three sections, beginning with the basis of epigenetic mechanisms and descriptions of epigenetic biomarkers that can be used in clinical diagnostics and prognostics. The second section refers to the importance of the sample quality and ethical issues in clinical epigenetics, with the final section presenting the technologies and methods to discover and analyze epigenetic biomarkers. The book describes the challenging aspects of epigenetic research and current findings regarding new epigenetic elements and modifiers, providing guidance for researchers interested in the most advanced technologies and methodologies used in the clinical diagnosis or prognosis of disease. Focuses on recent progress in several areas of epigenetics, general concepts regarding epigenetics, and the future prospects of this discipline in clinical diagnostics and prognostics Describes the importance of the quality of samples and clinical associated data, and also the ethical issues for epigenetic diagnostics Discusses the advances in epigenomics technologies, including next-generation sequencing based tools and applications Expounds on the utility of epigenetic biomarkers for diagnosis and prognosis of several diseases, highlighting the study of these biomarkers in cancer, cardiovascular and metabolic diseases, infertility, and infectious diseases Includes a special section that discusses the relevance of biobanks in the maintenance of high quality biosamples and clinical-associated data, and the relevance of the ethical aspects in epigenetic studies